General description

Prolactin (PRL) is a single-chain polypeptide of 226 amino acids with a molecular weight of about 24 kD. Prolactin plays a role in multiple processes including cell growth, reproduction, and immune function.¹ The pituitary hormone PRL is involved in tumorigenesis in rodents and humans. PRL promotes proliferation, survival, and migration of cancer cells acting via the PRL receptor.⁵ Anti-prolactin is a useful marker in classification of pituitary tumors and the study of pituitary disease as it reacts with prolactin-producing cells.^2-4 Such prolactin-producing cells can also be found in prostate epithelium.⁵

Legal Information

Cell Marque is a trademark of Sigma-Aldrich Co. LLC

Linkage

Prolactin Positive Control Slides, Product No. 210S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Other Notes

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Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and ﹤0.1% Sodium Azide.

Preparation Note

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Quality